PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX Erwan Delbarre, Kristina Ivanauskiene, Jane Spirkoski, Akshay Shah, Kristin Vekterud, Jan Øivind Moskaug, Stig Ove Bøe, Lee Wong, Thomas Küntziger and Philippe Collas Abstract Maintenance of chromatin homeostasis involves proper delivery of histone variants to the genome. The interplay between different chaperones…Read more
About: Monika Sekelja
Recent Posts by Monika Sekelja
Our Chrom3D genome structures visualized in Virtual Reality by master student Magnus Elden. https://youtu.be/eD8atMKqknARead more
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biology. 2017. 18:21. Abstract Current 3-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to…Read more
Rønningen T., Shah A, Oldenburg AR, Vekterud K, Delbarre E, Moskaug JØ, Collas P. 2015. Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B. Genome Res 25(12):1825-35. PMID: 26359231 Abstract Dynamic interactions of nuclear lamins with chromatin through lamin-associated domains (LADs) contribute to spatial arrangement of the genome. Here, we provide evidence…Read more
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