Histone H3.3 and chromatin homeostasis

Histone H3.3 and chromatin homeostasis

Histone H3 variants such as H3.3 contribute to the definition of chromatin domains. Dedicated histone H3.3 chaperones deposit H3.3 into specific genomic regions such as active genes, regulatory elements and heterochromatin. A form of pediatric gliomas called diffuse intrinsic pontine glioma (DIPG) is caused by mutations in H3.3, among which H3.3K27M is the most prominent. H3.3K27M leads to a global reduction of H3K27me3, but other effects on nuclear organization are not known.

Ongoing research:

  • Mechanisms of H3.3 deposition into chromatin
  • Impact of¬†DIPG-causing H3.3 mutations on nuclear architecture

Recent findings: