Project participants
Julia Madsen-Østerbye, Anita Sørensen, Kristin Vekterud, Mohamed Abdelhalim
Ongoing research
- Regulation of nuclear lamina interactions with chromatin via LADs and sub-LAD microdomains during adipose differentiation
- Role of A- and B-type lamins on lineage-specific differentiation of adipose stem cells
Our work relies on mechanistic cell biology and genomic approaches using engineered cell lines and primary mesenchymal stem cells.
Recent findings
- High-order rearrangement of chromatin domains when disrupting lamin-chromatin contacts
- Differential gene expression in LADs during adipogenesis (Madsen-Østerbye 2022 Genome Biol)
- Variable LADs are linked to adipose cell identity
- ChIP protocols for nuclear lamins (Oldenburg 2016 Method Mol Biol )
- Enriched domain detector (EDD) for identification of LADs from lamin ChIP-seq data (Lund 2014 Nucl Acids Res )