Philippe Collas, Thomas Germier, Louise Pedersen, Julia Madsen Østerbye, Mohamed Abdelhalim (collaboration with C. Campstein)
Image: the nuclear envelope and 3D chromatin modeling at the nuclear periphery
- Nuclear envelope reassembly after mitosis
- Mechanistic insight into the regulation of nuclear envelope interactions with chromatin
- Impacts of pathological disruptions of these interactions in laminopathies on chromatin integrity and (adipose) cell fate
Our work relies on mechanistic cell biology studies that include fixed- and live-cell microscopy, and genomics, functional and proteomics approaches using cell lines and primary cells.
- High-order rearrangement of chromatin domains when disrupting lamin-chromatin contacts