Nuclear envelope dynamics

Project participants

Philippe Collas, Thomas Germier, Louise Pedersen, Julia Madsen Østerbye, Mohamed Abdelhalim (collaboration with C. Campstein)

 

Image: the nuclear envelope and 3D chromatin modeling at the nuclear periphery

Ongoing research

  • Nuclear envelope reassembly after mitosis
  • Mechanistic insight into the regulation of nuclear envelope interactions with chromatin
  • Impacts of pathological disruptions of these interactions in laminopathies on chromatin integrity and (adipose) cell fate

Our work relies on mechanistic cell biology studies that include fixed- and live-cell microscopy, and genomics, functional and proteomics approaches using cell lines and primary cells.

Recent findings

  • High-order rearrangement of chromatin domains when disrupting lamin-chromatin contacts