Nuclear envelope dynamics

Project participants

Philippe Collas, Thomas Germier, Louise Pedersen; collaboration with Coen Campsteijn

 

Image: the nuclear envelope

Ongoing research

  • Temporal and mechanistic insight into the regulation of nuclear envelope assembly and integrity, and nuclear envelope interactions with chromatin, hereunder:
  • Components that contribute to nuclear envelope reassembly after mitosis
  • Maintenance of nuclear envelope-chromatin interphase
  • Mechanistic impacts of pathological disruptions of these interactions on chromatin integrity and cell fate

We do mechanistic cell biology studies that include fixed- and live-cell microscopy, functional and proteomics approaches using cell lines and primary cells.

Recent findings

  • High-order rearrangement of chromatin domains when disrupting lamin-chromatin contacts