Nuclear envelope integrity and genome stability

Project participants

Coen Campsteijn, Aurélie Bellanger, Louise Pedersen

Image: the nuclear envelope and adjacent foci of DNA damages (Coen Campsteijn)

Ongoing research

Our aim is to gain mechanistic and spatiotemporal insight into processes that control nuclear integrity and their contribution to genome stability. We focus on the following questions:

  • What factors contribute to nuclear envelope integrity during cell division and interphase?

  • How do these factors cooperate to sense and execute a functional reformation response?

  • What are the consequences of loss of nuclear envelope integrity for genome stability and cancer genome evolution?

We perform mechanistic cell biological studies that include live-cell microscopy, genetic manipulation, and proteomics approaches using non-transformed and cancer cell lines.