Portfolio Category: Nuclear integrity

Nuclear integrity and genome stability

Nuclear integrity and genome stability Project leader: Coen Campsteijn The nuclear envelope (NE) is the physical barrier that compartmentalizes the nucleus and protects the genome from damage. However, nuclear compartmentalization is compromised under various conditions, e.g. during open mitosis in many metazoans. Interphase cells also display reversible NE leaks, with increased frequency in cancer cells…
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