- Project leader:Dr. Aurélie Bellanger (lamin A and EMT), Dr. Marie Rogne (microproteins)
- Info:Levels of A-type nuclear lamins often vary between tumors and within tumors, but their roles in cancer development are unclear. We study the role of lamin A/C, as a genome organizer, in breast cancer progression through EMT. In addition, pioneer transcription factors are commonly dysregulated in cancer, and are often linked to cancer aggressiveness. We exploit biophysical properties of microproteins to target transcription factor activity in aggressive, treatment-resistant bone metastases.
Project participants
Dr. Aurélie Bellanger (lamin A and EMT), Dr. Marie Rogne (microproteins), Emily Martinsen, Tasmia Jinnurine, Dr. Mohamed Abdelhalim (bioinformatics)
Collaboration with Pioneer Research AS, Oslo
Ongoing research
- A-type lamins and transcription factor dynamics in a breast cancer model of EMT
- Relationship between the nuclear lamina, 3D genome organization and breast cancer progression
- Inhibition of transcription factors by microproteins in metastatic cancers
Recent findings
- Re-wiring of transcription factor networks by lamin A/C in a breast cancer EMT model (Bellanger, in prep)
- Loss of 3D genome organization at multiple levels in a model of breast cancer progression (Rossini 2026 Genome Res)
- A polymer model of chromatin to infer chromatin behavior at the nuclear lamina (Brunet 2021 Nucleus)
- Chrom3D: a platform for 3D genome modeling from Hi-C and LAD data (Paulsen 2017 Genome Biol; Paulsen 2018 Nature Protoc)
- Chrom3D on github: https://github.com/Chrom3D/Chrom3D