The 4D genome in the establishment of adipose cell identity

Project participants

Julia Madsen Østerbye, Aurélie Bellanger, Natalia Galigniana, Mohamed Abdelhalim, Anita Sørensen; collaborations with Jonas Paulsen, Institute of Biosciences, University of Oslo; Owen Marshall, University of Tasmania, Hobart; David Tremethick, Australian National University, Canberra; Lee H. Wong, Monash University, Melbourne

Ongoing research

  • Interplay between the nuclear lamina, LADs and TADs in the differentiation of adipose tissue and muscle stem cells
  • Control of gene expression at the nuclear lamina
  • Role of lamins on lineage-specific differentiation of adipose stem cells
  • Nuclear lamins and the epithelial-to-mesenchymal transition
  • Computational methods for 3D genome modeling

Recent findings