- Project leader:Dr. Aurélie Bellanger (lamin A and EMT), Dr. Marie Rogne (microproteins)
- Info:3D genome organization is altered in cancers. Levels of lamin A/C often vary between and within tumors, but their implications in cancer development are unclear. We study the role of lamin A/C, as a genome organizer, in breast cancer progression. In addition, pioneer transcription factors are commonly dysregulated in cancer, and are often linked to cancer aggressiveness. We exploit properties of microproteins and how they affect transcription factors to target transcription factor activity in aggressive bone metastases.
Project participants
Aurélie Bellanger (lamin A and EMT), Marie Rogne (Microproteins), Emily Martinsen, Tasmia Jinnurine, Mohamed Abdelhalim (bioinformatics)
Collaboration with Pioneer Research AS, Oslo
Ongoing research
- Nuclear lamin A/C and transcription factor dynamics in a breast cancer model of EMT
- Relationship between the nuclear lamina, 3D genome organization and breast cancer progression to metastasis
- Inhibition of transcription factors by microProteins in metastatic cancers
- Regulation of gene expression at the nuclear lamina
Recent findings
- Re-wiring of transcription factor networks by lamin A/C in a breast cancer EMT model (Bellanger, in prep)
- A polymer model of chromatin to infer chromatin behavior at the nuclear lamina (Brunet 2021 Nucleus)
- Chrom3D: a platform for 3D genome modeling from Hi-C and LAD data (Paulsen 2017 Genome Biol; Paulsen 2018 Nature Protoc)
- Chrom3D on github: https://github.com/Chrom3D/Chrom3D
- Mechanisms of H3.3 deposition into chromatin (Delbarre 2013 Genome Res; Ivanauskiene 2014 Genome Res); (Delbarre 2017 Genome Res)