The Stem Cell Epigenetics Lab: nuclear and genome architecture of adipogenesis and cancer metastasis

We investigate mechanisms by which genome organization and nuclear architecture pattern adipose stem cell fate, and cancer metastasis. We focus on the interplay between enhancer interactions, nuclear lamina-chromatin interactions, chromatin accessibility and transcription factor binding and activity. Our main model systems are i) white and beige differentiation of adipose stem cells from healthy individuals and lipodystrophy patients, ii) in vitro models of EMT and iii) metastatic cancer cell lines.

Keywords: adipogenesis, 3D enhancer connections, nuclear lamina, LADs, laminopathies, transcription factors, EMT, metastasis

Meet our team >>

Philippe Collas, Professor, Head of lab

Head, Institute of Basic Medical Sciences

Our current projects

We combine molecular, microscopy, genomics and bioinformatics approaches using human adipose stem cells and cancer cell lines.

News

• New presentation at the 100th Society for Experimental Biology meeting in Edinburgh, UK

  Invited lecture (Philippe): Gene regulatory interactions at lamina-associated domains

• We speak at the Gordon Research Conference on Genome architecture in cell fate and disease 2023, in Ventura, CA, USA

  Invited lecture (Philippe): The dynamic 3D genome: a tale of LADs

• New presentation at the 4th International Meeting on Laminopathies, Madrid, Spain

  Invited lecture (Philippe): Chromatin (de)regulation in laminopathies