Nuclear and chromatin architecture of adipogenesis and cancer
We investigate mechanisms by which high-order and local features of nuclear architecture pattern lineage determination in health and disease, including adipogenesis, lipodystrophic laminopathies and the epithelial-to-mesenchymal transition.
Read more >>Meet our team >>
Philippe Collas, Professor, Principal Investigator
Chair, Department of Molecular Medicine
Mailing address:
University of Oslo
Institute of Basic Medical Sciences
Department of Molecular Medicine
PO Box 1112 Blindern
0317 Oslo, Norway
Visiting address:
University of Oslo
Domus Medica, 2nd floor, room 2250
Sognvannsveien 9
0372 Oslo, Norway
Public transport: Tram lines 17 and 18 to Rikshospitalet; get off at the end station and walk 2 min to Domus Medica.
Phone: +47 22851060 (Administrative assistant)
philc [at] medisin.uio.no
s.m.taraldsen [at] medisin.uio.no (Administrative assistant)
s.m.taraldsen [at] medisin.uio.no (Administrative assistant)
We are working in the following areas:
Our work combines molecular, genomics, imaging and bioinformatics approaches using patient material and engineered stem cells from human adipose tissue.
Go to research >>Funding
- University of Oslo
- The Research Council of Norway
- The Norwegian Cancer Society
- South-East Health Norway
News
Our newest paper on the LncRNA HOTAIR and adipogenesis is out!
The lncRNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, but its significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced…Check out our publication on LAD repositioning during adipogenic differentiation
Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on…Check out our two newest reviews on nuclear lamina-chromatin interactions
Biology and model predictions of the dynamics and heterogeneity of chromatin-nuclear lamina interactions. Julia Madsen-Østerbye et al. 2022. Frontiers Cell Dev Biol 10:913458. doi: 10.3389/fcell.2022.913458; https://pubmed.ncbi.nlm.nih.gov/35710716/ Restructuring of Lamina-Associated Domains…
Our newest paper on the LncRNA HOTAIR and adipogenesis is out!
The lncRNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, but its significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced…
Check out our publication on LAD repositioning during adipogenic differentiation
Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on…
Check out our two newest reviews on nuclear lamina-chromatin interactions
Biology and model predictions of the dynamics and heterogeneity of chromatin-nuclear lamina interactions. Julia Madsen-Østerbye et al. 2022. Frontiers Cell Dev Biol 10:913458. doi: 10.3389/fcell.2022.913458; https://pubmed.ncbi.nlm.nih.gov/35710716/ Restructuring of Lamina-Associated Domains…