Welcome to CollasLab

Nuclear architecture of adipogenesis

bureauxWe investigate mechanisms by which 3D nuclear architecture patterns differentiation of adipose progenitor cells into specific adipocyte sub-types, such as lipid-storing white adipocytes and thermogenic beige adipocytes.  We examine how mutations in nuclear lamins causing familial partial lipodystrophy (FPLD2, a subset of laminopathies) affect chromatin architecture and adipogenic differentiation in upper and lower body fat depots. We also study aspects of nuclear envelope dynamics.
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Meet our team >>

Philippe Collas, Professor, Head of Laboratory

Mailing address:
University of Oslo
Institute of Basic Medical Sciences
Department of Molecular Medicine
PO Box 1112 Blindern
0317 Oslo, Norway

Visiting address:
University of Oslo
Domus Medica, 2nd floor, room 2250
Sognvannsveien 9
0372 Oslo, Norway

Public transport: Tram lines 17 and 18 to Rikshospitalet; get off at the end station and walk to Domus Medica.

Phone: +47 22851060 (Administrative assistant)

philc [at] medisin.uio.no
s.m.taraldsen [at] medisin.uio.no (Administrative assistant)

We are working in the following areas:

Processes underlying 3D genome conformation

Regulation of adipocyte function by chromatin

Nuclear architecture in lipodystrophic laminopathies 

Nuclear envelope dynamics                                                  

Our work combines molecular, genomics, imaging and computational modeling approaches using patient material and engineered progenitor cells isolated from human adipose tissue.

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Funding

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