The Stem Cell Epigenetics Lab: Nuclear and chromatin architecture of adipogenesis and cancer cells

We investigate mechanisms by which features of chromatin organization and of nuclear architecture pattern adipose stem cell fate, EMT and cancer metastasis. We focus on the interplay between 3D chromatin interactions (including enhancer connectivity), nuclear lamina-chromatin interactions (including LADs), chromatin accessibility and transcription factor binding dynamics. Our model systems are multilineage differentiation of adipose stem cells (e.g. white vs. beige lineages), breast epithelial cell models of EMT, and various cancer cell types.

Keywords: 3D chromatin, enhancer-enhancer connections, nuclear lamina, LADs, adipose cells, laminopathies, epithelial-to-mesenchymal transition, metastasis.

Meet our team >>

Philippe Collas, Professor, Principal Investigator

Chair, Department of Molecular Medicine

Our current projects

Our work combines molecular, imaging, genomics and bioinformatics approaches using patient material, human adipose stem cells and cancer cell lines.

Funding

• University of Oslo
• The Research Council of Norway
• The Norwegian Cancer Society
• South-East Health Norway

News

• New presentation at the 100th Society for Experimental Biology meeting in Edinburgh, UK

  Invited lecture (Philippe): Gene regulatory interactions at lamina-associated domains

• We speak at the Gordon Research Conference on Genome architecture in cell fate and disease 2023, in Ventura, CA, USA

  Invited lecture (Philippe): The dynamic 3D genome: a tale of LADs

• New presentation at the 4th International Meeting on Laminopathies, Madrid, Spain

  Invited lecture (Philippe): Chromatin (de)regulation in laminopathies