Collaborations

  • Brigitte Buendia, Université Paris Diderot, CNRS, Paris, France (nuclear envelope )
  • Louis Casteilla, StromaLab (adipose tissue metabolism)
  • Jacques Grill, Institut Gustave Roussy, Villejuif, France (pediatric glioblastoma)
  • Axel Imhof, Ludvig Maximilian University, Munich, Germany (proteomics)
  • Andrey Karsakov, ITMO University, St. Petersburg, Russia (visualization tools)
  • Ashby Morrison, Stanford University (UV-induced DNA lesion mapping)
  • Stefan Pfister, DKFZ, Heidelberg, Germany (pediatric glioblastoma)
  • Corinne Vigouroux, Hôpital Saint Antoine, INSERM, Paris, France (lipodystrophic laminopathies)
  • Lee Wong, Monash University, Clayton, Australia (histone variants and pediatric glioblastoma)
  • Steven Turner, Monash University, Clayton, Australia (genome conformation and T cell differentiation)
  • David Tremethick, John Curtis School of Medical Research, Australian National University, Canberra, Australia (genome conformation, histone variants)
  • 3D genome modeling

    3D genome modeling

    We are developing new computational methods for 3D and 4D modeling of genome structure to characterize relationships between 3D chromatin folding patterns, nuclear envelope-chromatin interactions and epigenetic states during lineage-specific differentiation.

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  • Nuclear integrity and genome stability

    Nuclear integrity and genome stability

    Nuclear integrity and genome stability Project leader: Coen Campsteijn The nuclear envelope (NE) constitutes the physical barrier that compartmentalizes the nucleus and protects the genome from damage. However, nuclear compartmentalization is compromised under various conditions, the classical example of which is the open mitosis of many metazoans. More recently, interphase…

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  • Nuclear lamins, laminopathies & adipose stem cells

    Nuclear lamins, laminopathies & adipose stem cells

    We are working on identifying determinants of nuclear envelope-chromatin interactions during lineage-specific differentiation and in laminopathy contexts.

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  • Histone variants and chromatin homeostasis

    Histone variants and chromatin homeostasis

    We aim to unveil pathways of loading and incorporation of H3.3 into chromatin, and determine how H3.3 contributes to the maintenance of heterochromatin states in the genome. We also aim to understand the impact of DIPG H3.3 mutations on genome and nuclear organization in pediatric glioblastomas.

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