• Louis Casteilla, StromaLab, University of Toulouse (adipose tissue metabolism)
  • Jacques Grill, Institut Gustave Roussy, Villejuif, France (pediatric glioblastoma)
  • Axel Imhof, Ludvig Maximilian University, Munich, Germany (proteomics)
  • Andrey Karsakov, ITMO University, St. Petersburg, Russia (genome visualization)
  • Ashby Morrison, Stanford University (DNA lesion mapping)
  • Stefan Pfister, DKFZ, Heidelberg, Germany (pediatric glioblastoma)
  • Kjetil Taskén, Oslo University Hospital (cAMP signaling through PKA)
  • David Tremethick, John Curtis School of Medical Research, Australian National University, Canberra, Australia (genome conformation, histone variants)
  • Steven Turner, Monash University, Clayton, Australia (genome conformation and T cell differentiation)
  • Corinne Vigouroux, Hôpital Saint Antoine, INSERM, Paris, France (lipodystrophic laminopathies)
  • Lee Wong, Monash University, Clayton, Australia (H3.3 variants and pediatric glioblastoma)
  • Histone variants and chromatin homeostasis

    Histone variants and chromatin homeostasis

    We aim to unveil pathways of loading and incorporation of H3.3 into chromatin, and determine how H3.3 contributes to the maintenance of heterochromatin states in the genome. We also aim to understand the impact of DIPG H3.3 mutations on genome and nuclear organization in pediatric glioblastomas.

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  • 3D genome modeling

    3D genome modeling

    We are developing new computational methods for 3D and 4D modeling of genome structure to characterize relationships between 3D chromatin folding patterns, nuclear envelope-chromatin interactions and epigenetic states during lineage-specific differentiation.

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  • Nuclear lamins, laminopathies & adipose stem cells

    Nuclear lamins, laminopathies & adipose stem cells

    We are working on identifying determinants of nuclear envelope-chromatin interactions during lineage-specific differentiation and in laminopathy contexts.

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  • Nuclear integrity and genome stability

    Nuclear integrity and genome stability

    Nuclear integrity and genome stability Project leader: Coen Campsteijn The nuclear envelope (NE) is the physical barrier that compartmentalizes the nucleus and protects the genome from damage. However, nuclear compartmentalization is compromised under various conditions, e.g. during open mitosis in many metazoans. Interphase cells also display reversible NE leaks, with…

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