Collaborations

  • Louis Casteilla, StromaLab, University of Toulouse (adipose tissue metabolism)
  • Jacques Grill, Institut Gustave Roussy, Villejuif, France (pediatric glioblastoma)
  • Axel Imhof, Ludvig Maximilian University, Munich, Germany (proteomics)
  • Andrey Karsakov, ITMO University, St. Petersburg, Russia (genome visualization)
  • Ashby Morrison, Stanford University (DNA lesion mapping)
  • Stefan Pfister, DKFZ, Heidelberg, Germany (pediatric glioblastoma)
  • Kjetil Taskén, Oslo University Hospital (cAMP signaling through PKA)
  • David Tremethick, John Curtis School of Medical Research, Australian National University, Canberra, Australia (genome conformation, histone variants)
  • Steven Turner, Monash University, Clayton, Australia (genome conformation and T cell differentiation)
  • Corinne Vigouroux, Hôpital Saint Antoine, INSERM, Paris, France (lipodystrophic laminopathies)
  • Lee Wong, Monash University, Clayton, Australia (H3.3 variants and pediatric glioblastoma)
  • Regulation of transcription by sugars and fatty acids

    Regulation of transcription by sugars and fatty acids

    We examine how fatty acids and glucose regulate gene expression through the transcription regulators SHREB and LXR.

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  • Nuclear integrity and genome stability

    Nuclear integrity and genome stability

    We investigate mechanistic and spatiotemporal processes that control nuclear integrity and their contribution to genome stability.

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  • Computational 3D genome modeling

    Computational 3D genome modeling

    We develop computational methods for 3D and 4D modeling of genome structure to characterize relationships between 3D chromatin architecture and epigenetic states during differentiation and in cancer cells.

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  • Nuclear lamins, laminopathies & adipose tissue regulation

    Nuclear lamins, laminopathies & adipose tissue regulation

    We are studying how the nuclear lamina regulates spatial chromatin organization and gene expression during adipose stem cell differentiation and in lipodystrophic laminopathies.

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  • Histone H3.3 and chromatin homeostasis

    Histone H3.3 and chromatin homeostasis

    We study pathways of H3.3 incorporation into chromatin and how H3.3 contributes to the maintenance of heterochromatin states. We also examine the impact of H3.3 mutations on genome and nuclear organization in pediatric glioblastomas (DIPGs).

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