Collaborations

  • Louis Casteilla, StromaLab, University of Toulouse, France
  • Nicolas Destainville, University of Toulouse, France
  • Jacques Grill, Institut Gustave Roussy, Villejuif, France
  • Andrey Karsakov, ITMO University, St. Petersburg, Russia
  • Vessela Kristensen, Oslo University Hospital, Oslo, Norway
  • Ashby Morrison, Stanford University, CA, USA
  • Stefan Pfister, DKFZ, Heidelberg, Germany
  • Kjetil Taskén, Oslo University Hospital, Oslo, Norway
  • David Tremethick, The Australian National University, Canberra, Australia
  • Steven Turner, Monash University, Clayton, Australia
  • Corinne Vigouroux, Hôpital Saint Antoine, INSERM, Paris, France
  • Lee Wong, Monash University, Clayton, Australia
  • Regulation of transcription by sugars and fatty acids

    Regulation of transcription by sugars and fatty acids

    We examine how fatty acids and glucose regulate gene expression through the transcription regulators SHREB and LXR.

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  • Nuclear integrity and genome stability

    Nuclear integrity and genome stability

    We investigate mechanistic and spatiotemporal processes that control nuclear integrity and their contribution to genome stability.

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  • Nuclear lamins, laminopathies & adipose tissue regulation

    Nuclear lamins, laminopathies & adipose tissue regulation

    We are studying how the nuclear lamina regulates spatial chromatin organization and gene expression during adipose stem cell differentiation and in lipodystrophic laminopathies.

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  • Computational 3D genome modeling

    Computational 3D genome modeling

    We develop computational methods for 3D and 4D modeling of genome structure to characterize relationships between 3D chromatin architecture and epigenetic states during differentiation and in cancer cells.

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  • Histone H3.3 and chromatin homeostasis

    Histone H3.3 and chromatin homeostasis

    We study pathways of H3.3 incorporation into chromatin and how H3.3 contributes to the maintenance of heterochromatin states. We also examine the impact of H3.3 mutations on genome and nuclear organization in pediatric glioblastomas (DIPGs).

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