3D genome conformation

Project participants

Julia Madsen Østerbye, Aurélie Bellanger, Natalia Galigniana, Mohamed Abdelhalim, Kristin Vekterud; collaborations with Jonas Paulsen (Institute of Biosciences, University of Oslo); David Tremethick, Australian National University, Canberra; Lee H. Wong (Monash University, Melbourne); Erwan Delbarre (Oslo Metropolitan University); Jacques Grill (Institut Gustave Roussy, Paris) 

Image: 3D structural model of the genome in a human fibroblast nucleus. Model generated using our Chrom3D software, from Hi-C and lamin ChIP-seq input data to infer chromosomal interactions and positioning of chromatin domains towards the nuclear periphery. Each chromosome is labeled in a different color.

Ongoing research

  • Interplay between genomic organizers such as the nuclear envelope, LADs and TADs on nuclear architecture in stem cells and cancer cells
  • Mechanism of formation and disassembly of TAD cliques
  • Role of histone variant H3.3 on radial chromatin organization
  • Computational methods for 3D genome modeling

Recent findings