4D genome conformation

Project participants

Julia Madsen Østerbye, Aurélie Bellanger, Natalia Galigniana, Mohamed Abdelhalim, Kristin Vekterud, Anita Sørensen; collaborations with Jonas Paulsen (Institute of Biosciences, University of Oslo); Erwan Delbarre, Oslo Metropolitan University; David Tremethick, Australian National University, Canberra; Lee H. Wong, Monash University, Melbourne

Image: 3D model of chromatin in a human fibroblast nucleus. Model generated using Chrom3D , from Hi-C and lamin ChIP-seq data to infer chromosomal interactions and positioning of chromatin towards the nuclear periphery.

Ongoing research

  • Interplay between the nuclear lamina, LADs and TADs as genomic organizers in stem cells and cancer cells
  • Formation and disassembly of TAD cliques during differentiation
  • Nuclear lamins and EMT
  • Histone variant H3.3 and chromatin organization in pediatric glioblastomas
  • Computational methods for 3D genome modeling

Recent findings