Monthly Archives: December 2020

Our review on lamina-associated domains (LADs) is out in Genome Biology

Lamina-associated domains: peripheral matters and internal affairs. Briand N, Collas P. Genome Biol. 2020 Apr 2;21(1):85. doi: 10.1186/s13059-020-02003-5. At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell…
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Our review on FPLD2 laminopathy and nuclear architecture

Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois. Briand N, Cahyani I, Madsen-Østerbye J, Paulsen J, Rønningen T, Sørensen AL, Collas P. Front Cell Dev Biol. 2018 Jul 9;6:73. doi: 10.3389/fcell.2018.00073.  At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also…
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