Category Archives: Publications

Our review on lamina-associated domains (LADs) is out in Genome Biology

Lamina-associated domains: peripheral matters and internal affairs. Briand N, Collas P. Genome Biol. 2020 Apr 2;21(1):85. doi: 10.1186/s13059-020-02003-5. At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell…
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Our review on FPLD2 laminopathy and nuclear architecture

Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois. Briand N, Cahyani I, Madsen-Østerbye J, Paulsen J, Rønningen T, Sørensen AL, Collas P. Front Cell Dev Biol. 2018 Jul 9;6:73. doi: 10.3389/fcell.2018.00073.  At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also…
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Cliques of topologically associating domains (TADs) form repressed chromatin domains towards the nuclear periphery

Nat Genet. 2019 May;51(5):835-843. doi: 10.1038/s41588-019-0392-0. Long-range interactions between topologically associating domains shape the 4-dimensional genome during differentiation Jonas Paulsen, Tharvesh M. Liyakat Ali, Maxim Nekrasov, Erwan Delbarre, Marie-Odile Baudement, Sebastian Kurscheid, David Tremethick and Philippe Collas A collaboration between the University of Oslo (Collas) and The Australian National University (Tremethick) Genomic information is selectively…
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Lipodystrophic (FPLD2) lamin A mutation deregulates an anti-adipogenic microRNA in adipocyte progenitors

  J Cell Biol. 2017 Sep 4;216(9):2731-2743. doi: 10.1083/jcb.201701043. Epub 2017 Jul 27. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. Oldenburg A1, Briand N1, Sørensen AL1, Cahyani I1, Shah A1, Moskaug JØ1,2, Collas P3,2. Abstract Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which…
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