3D genome organization is shaped by dynamic interactions with multiple structures in the nucleus, affecting gene expression outcomes. Technological breakthroughs have generated vast datasets reflecting various aspects of nuclear genome architecture in space and time. This paper is a step-by-step guide on how to generate publication-ready integrated 3D genome models from (raw) Hi-C data and…
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Check out our latest paper on how TAD cliques predict key features of chromatin organization
Our paper characterizing the genomic composition of so-called TAD cliques (Paulsen et al. 2019 Nat Genet) is out in BMC Genomics (Liyakat Ali et al. 2021 BMC Genomics 22, 499; doi: 10.1186/s12864-021-07815-8).
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Our latest paper on polymer modeling of chromatin at the nuclear lamina is out!
Check out Annaël Brunet's latest paper from our lab, on the biophysical properties of a chromatin polymer interacting with a surface representing the nuclear lamina. The work results from a collaboration with Prof. Nicolas Destainville, Université Paul Sabatier, Toulouse, France. Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale…
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