We combine molecular/cell biology, microscopy imaging and genomics approaches to identify how the 3D genome evolves during multilineage stem cell differentiation. We investigate how the nuclear lamina and LADs contribute to the determination of adipose cell fate and cell identity.
Epigenetic control of the white-to-beige adipocyte conversion
We examine 3D epigenetic mechanisms regulating progenitor fate specification in adipose tissues, as well as white vs. thermogenic beige adipogenesis.