Project participants
Nolwenn Briand, Louise Petersen, Julia Madsen-Østerbye, Anita Sørensen; collaborations with Coen Campsteijn (U Oslo), Corinne Vigouroux and Isabelle Jéru (INSERM & Université Pierre et Marie Curie, Paris)
Ongoing research
- Impact of FPLD2-causing lamin A p.R482W mutation on functional nuclear and chromatin architecture during adipogenesis and in adipocytes
- Impact of lamin A p.R482W on nuclear envelope integrity
Recent achievements
- FLPD2-causing lamin A p.R482W mutation deregulates vascular differentiation gene networks in an iPS cell model of FPLD2 (Briand, Guénantin 2018 Hum Moll Genet)
- Lamin A p.R482W alters radial positioning of loci in FPLD2 patient fibroblasts (Paulsen 2017 Genome Biol)
- Lamin A mutation deregulates epigenetic and spatial conformation of anti-adipogenic MIR335 locus (Oldenburg 2017 J Cell Biol)
- ChIP protocol for nuclear lamins (Oldenburg 2016 Meth Mol Biol)
- Lamin A mutation deregulates SREBP1 activity in FPLD2 (Vadrot 2015 Hum Mol Genet)
- Lamin A mutation alters lamin A interactome of and deregulates FXR1 (Oldenburg 2014 Hum Mol Genet)