We investigate how the nuclear lamina and LADs contribute to the determination of cell fate and cell identity in normal and cancer cells.
Nuclear lamins and establishment of cell fate and cell identity
Nuclear architecture of white and beige adipocyte function
We examine chromatin-linked mechanisms regulating progenitor fate specification in various adipose tissues, as well as white vs. thermogenic beige adipogenesis.
Deregulation of chromatin architecture in lipodystrophic laminopathies caused by lamin A mutations
We study how the LMNA p.R482W mutation affects spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes