Using mouse models of sleep deprivation, we are studying how the detrimental effect of adolescence sleep deprivation on adult metabolic health is epigenetically encoded during adolescence and is recalled later in life.
We combine molecular/cell biology, microscopy imaging and genomics approaches to identify how the 3D genome evolves during multilineage stem cell differentiation. We investigate how the nuclear lamina and LADs contribute to the determination of adipose cell fate and cell identity.
We examine 3D epigenetic mechanisms regulating progenitor fate specification in adipose tissues, as well as white vs. thermogenic beige adipogenesis.
We study how mutations in lamin A/C affect spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes; we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation.