Portfolio Category: Adipose stem cells

The 4D genome in the establishment of adipose cell identity

We combine molecular/cell biology, microscopy imaging and genomics approaches to identify how the 3D genome evolves during multilineage stem cell differentiation. We investigate how the nuclear lamina and LADs contribute to the determination of adipose cell fate and cell identity.

Read more

Chromatin architecture in laminopathies: a tale of LADs

We study how mutations in lamin A/C affect spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes; we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation.

Read more