J Cell Biol. 2017 Sep 4;216(9):2731-2743. doi: 10.1083/jcb.201701043. Epub 2017 Jul 27. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. Oldenburg A1, Briand N1, Sørensen AL1, Cahyani I1, Shah A1, Moskaug JØ1,2, Collas P3,2. Abstract Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which…
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About: Philippe Collas
Recent Posts by Philippe Collas
Lipodystrophic Lamin A mutation deregulates mesodermal differentiation in iPS cell model of FPLD2
Hum Mol Genet. 2018 Apr 15;27(8):1447-1459. doi: 10.1093/hmg/ddy055. The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks. Briand N1,2, Guénantin AC2,3, Jeziorowska D4, Shah A1, Mantecon M2, Capel E2, Garcia M2, Oldenburg A1, Paulsen J1, Hulot JS4, Vigouroux C2,5, Collas P1,6. Abstract The p.R482W hotspot mutation…
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Chrom3D protocol published in Nature Protocols
Computational 3D genome modeling using Chrom3D Nat Protoc. 2018 May;13(5):1137-1152. doi: 10.1038/nprot.2018.009. Epub 2018 Apr 26. Paulsen J1, Liyakat Ali TM1, Collas P1,2. 1 Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. 2 Department of Immunology, Oslo University Hospital, Oslo, Norway. Chrom3D is a computational platform…
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Our review on the 4D nucleome in single cells
Sekelja M, Paulsen J, Collas P. 2016. 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation? Genome Biol. 2016, 17:54. PMID:27052789 Abstract: Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single…
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