Category Archives: Latest publications

Latest paper in Genome Research

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX Erwan Delbarre, Kristina Ivanauskiene, Jane Spirkoski, Akshay Shah, Kristin Vekterud, Jan Øivind Moskaug, Stig Ove Bøe, Lee Wong, Thomas Küntziger and Philippe Collas Abstract Maintenance of chromatin homeostasis involves proper delivery of histone variants to the genome. The interplay between different chaperones…
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Chrom3D: a user-friendly whole-genome 3D computational modeling framework

Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biology. 2017. 18:21. Abstract Current 3-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to…
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Our review on the 4D nucleome in single cells

Sekelja M, Paulsen J, Collas P. 2016. 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation? Genome Biol. 2016, 17:54. PMID:27052789 Abstract: Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single…
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Paper on H3.3 and chromatin

Ivanauskiene, K., Delbarre, E., McGhie, J.D., Küntziger, T., Wong, L.H., and Collas, P. The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Research. 24: 1584-94   [caption id="attachment_2383" align="alignleft" width="440"] Model of regulation of loading of H3.3 on chromatin by DEK. (A) Outside telomeres, DEK…
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