The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How these genes are regulated and whether they are able to interact with regulatory elements remain unclear. Here, we integrate publicly available…
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Our two papers on the LncRNA HOTAIR and adipogenesis is out!
The lncRNA HOTAIR is the most differentially expressed gene between upper- and lower-body adipose tissue, but its significance in adipogenesis is unclear. We report that HOTAIR expression is transiently induced during early adipogenic differentiation of gluteofemoral adipose progenitors and is repressed in mature adipocytes. Upon adipogenic commitment, HOTAIR regulates protein synthesis pathways and cytoskeleton remodeling…
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Our review on lamina-associated domains (LADs) is out in Genome Biology
Lamina-associated domains: peripheral matters and internal affairs. Briand N, Collas P. Genome Biol. 2020 Apr 2;21(1):85. doi: 10.1186/s13059-020-02003-5. At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell…
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Cliques of topologically associating domains (TADs) form repressed chromatin domains towards the nuclear periphery
Nat Genet. 2019 May;51(5):835-843. doi: 10.1038/s41588-019-0392-0. Long-range interactions between topologically associating domains shape the 4-dimensional genome during differentiation Jonas Paulsen, Tharvesh M. Liyakat Ali, Maxim Nekrasov, Erwan Delbarre, Marie-Odile Baudement, Sebastian Kurscheid, David Tremethick and Philippe Collas A collaboration between the University of Oslo (Collas) and The Australian National University (Tremethick) Genomic information is selectively…
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