Monthly Archives: December 2020

Our review on lamina-associated domains (LADs) is out in Genome Biology

Lamina-associated domains: peripheral matters and internal affairs. Briand N, Collas P. Genome Biol. 2020 Apr 2;21(1):85. doi: 10.1186/s13059-020-02003-5. At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell…
Read more

Nuclear lamin-chromatin interactions during the circadian cycle

Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression. Brunet A, Forsberg F, Fan Q, Sæther T, Collas P. Front Genet. 2019 Oct 3;10:917. doi: 10.3389/fgene.2019.00917 Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate…
Read more

Our review on FPLD2 laminopathy and nuclear architecture

Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois. Briand N, Cahyani I, Madsen-Østerbye J, Paulsen J, Rønningen T, Sørensen AL, Collas P. Front Cell Dev Biol. 2018 Jul 9;6:73. doi: 10.3389/fcell.2018.00073.  At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also…
Read more