3D genome organization is shaped by dynamic interactions with multiple structures in the nucleus, affecting gene expression outcomes. Technological breakthroughs have generated vast datasets reflecting various aspects of nuclear genome architecture in space and time. This paper is a step-by-step guide on how to generate publication-ready integrated 3D genome models from (raw) Hi-C data and…
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Check out our latest paper on how TAD cliques predict key features of chromatin organization
Our paper characterizing the genomic composition of so-called TAD cliques (Paulsen et al. 2019 Nat Genet) is out in BMC Genomics (Liyakat Ali et al. 2021 BMC Genomics 22, 499; doi: 10.1186/s12864-021-07815-8).
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