Recent Posts by Philippe Collas

Our latest review on TAD cliques

Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression. Brunet A, Forsberg F, Fan Q, Sæther T, Collas P. Front Genet. 2019 Oct 3;10:917. doi: 10.3389/fgene.2019.00917. eCollection 2019. The mammalian genome is intricately folded in a three-dimensional topology believed to be important for the orchestration of gene expression regulating…
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Cliques of topologically associating domains (TADs) form repressed chromatin domains towards the nuclear periphery

Nat Genet. 2019 May;51(5):835-843. doi: 10.1038/s41588-019-0392-0. Long-range interactions between topologically associating domains shape the 4-dimensional genome during differentiation Jonas Paulsen, Tharvesh M. Liyakat Ali, Maxim Nekrasov, Erwan Delbarre, Marie-Odile Baudement, Sebastian Kurscheid, David Tremethick and Philippe Collas A collaboration between the University of Oslo (Collas) and The Australian National University (Tremethick) Genomic information is selectively…
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Lipodystrophic (FPLD2) lamin A mutation deregulates an anti-adipogenic microRNA in adipocyte progenitors

  J Cell Biol. 2017 Sep 4;216(9):2731-2743. doi: 10.1083/jcb.201701043. Epub 2017 Jul 27. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. Oldenburg A1, Briand N1, Sørensen AL1, Cahyani I1, Shah A1, Moskaug JØ1,2, Collas P3,2. Abstract Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which…
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Lipodystrophic lamin A mutation deregulates mesodermal differentiation in an iPS cell model of FPLD2

Hum Mol Genet. 2018 Apr 15;27(8):1447-1459. doi: 10.1093/hmg/ddy055. The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks. Briand N1,2, Guénantin AC2,3, Jeziorowska D4, Shah A1, Mantecon M2, Capel E2, Garcia M2, Oldenburg A1, Paulsen J1, Hulot JS4, Vigouroux C2,5, Collas P1,6. Abstract The p.R482W hotspot mutation…
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