Check out Annaël Brunet's latest paper from our lab, on the biophysical properties of a chromatin polymer interacting with a surface representing the nuclear lamina. The work results from a collaboration with Prof. Nicolas Destainville, Université Paul Sabatier, Toulouse, France. Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale…
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About: Philippe Collas
Recent Posts by Philippe Collas
New 4-year funding from the Research Council of Norway to work on the epigenetic regulation of adipose tissue beiging
Philippe Collas and Nolwenn Briand, project group leader in the lab and co-PI on the grant, have obtained funding from the Research Council to study epigenetic mechanisms associated with the beiging of white adipose tissue.
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Our review on lamina-associated domains (LADs) is out in Genome Biology
Lamina-associated domains: peripheral matters and internal affairs. Briand N, Collas P. Genome Biol. 2020 Apr 2;21(1):85. doi: 10.1186/s13059-020-02003-5. At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell…
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Cliques of topologically associating domains (TADs) form repressed chromatin domains towards the nuclear periphery
Nat Genet. 2019 May;51(5):835-843. doi: 10.1038/s41588-019-0392-0. Long-range interactions between topologically associating domains shape the 4-dimensional genome during differentiation Jonas Paulsen, Tharvesh M. Liyakat Ali, Maxim Nekrasov, Erwan Delbarre, Marie-Odile Baudement, Sebastian Kurscheid, David Tremethick and Philippe Collas A collaboration between the University of Oslo (Collas) and The Australian National University (Tremethick) Genomic information is selectively…
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