We examine 3D epigenetic mechanisms regulating adipose progenitor fate specification , and in white vs. thermogenic beige adipogenesis.
3D epigenetic control of white / beige adipocyte identity
Genome organization in laminopathies
We study how mutations in lamin A/C affect spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes; we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation.