We are studying how the nuclear lamina regulates spatial chromatin organization and gene expression during adipose stem cell differentiation and in lipodystrophic laminopathies.
Nuclear lamins, laminopathies & adipose tissue regulation
Computational 3D genome modeling
We develop computational methods for 3D and 4D modeling of genome structure to characterize relationships between 3D chromatin architecture and epigenetic states during differentiation and in cancer cells.