Using mouse models of sleep deprivation, we study how the detrimental effect of adolescence sleep deprivation on adult metabolic health is epigenetically encoded in the young and recalled later in life.
We examine 3D epigenetic mechanisms regulating adipose progenitor fate specification , and in white vs. thermogenic beige adipogenesis.
We study how mutations in lamin A/C affect spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes; we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation.