We examine how fatty acids and glucose regulate gene expression through the transcription regulators SHREB and LXR.
We investigate mechanistic and spatiotemporal processes that control nuclear integrity and their contribution to genome stability.
We are studying how the nuclear lamina regulates spatial chromatin organization and gene expression during adipose stem cell differentiation and in lipodystrophic laminopathies.
We study pathways of H3.3 incorporation into chromatin and how H3.3 contributes to the maintenance of heterochromatin states. We also examine the impact of H3.3 mutations on genome and nuclear organization in pediatric glioblastomas (DIPGs).