We combine molecular/cell biology, imaging and genomics approaches to determine how nuclear lamins and microProteins regulate pioneer transcription factor activity and transcription factor networks implicated in EMT and cancer metastasis.
We examine 3D epigenetic mechanisms regulating progenitor fate specification in adipose tissues, as well as white vs. thermogenic beige adipogenesis.
We study how mutations in lamin A/C affect spatial chromatin organization, the epigenome and gene expression regulation in adipose progenitors and adipocytes; we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation.